MMW Fortschritte der Medizin
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Biography Historical Article
[Physician and resistance fighter. Late rehabilitation for a courageous physician].
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Review Comparative Study
[Evidence-based pharmacotherapy of neuropathic pain syndromes].
Neuropathic pain can severely reduce quality of life. Double blind, placebo controlled studies confirm the efficacy of the treatment of painful neuropathy, postherpetic neuralgia and trigeminal neuralgia with tricyclic antidepressants, ion channel blockers, opioids and lipoic acid. The numbers-needed-to-treat (NNT) with monotherapy to achieve pain reduction of at least 50% are in the range of 2 to 4. Recent studies indicate that patients can benefit from combinations of opioids and tricyclic antidepressants or opioids and gabapentin.
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Comparative Study
[Pain reduced and quality of life improved by sustained-release hydromorphone. Results of an observational study].
A total of 487 patients with severe pain of varying pathogenesis received sustained-release hydromorphone (Palladon) in an observational study. After an initial examination, two follow-ups took place on the 3rd and 7th day and a final examination after about 21 days. ⋯ This observational study confirms the good pain-relieving efficacy of sustained-release hydromorphone together with very good tolerability and very good compliance. Patients assessed their own quality of life as markedly improved.