Przegla̧d lekarski
-
Multicenter Study
[The health state evaluation in persons after therapy of Hodgkin's disease in childhood: report of the Polish Pediatric Leukemia/Lymphoma Study Group].
The introduction of modern methods of combined therapy: chemotherapy and radiotherapy, allows the cure more than 90% of children and adolescents with Hodgkin's disease. However, the intensive treatment may cause early and late complications. The late complications may include: damage of soft tissues and respiratory, cardiovascular, skeletal, and endocrine systems, and second cancers. ⋯ Second cancers were diagnosed in 1.7% of patients. The health status of children and adolescents cured from Hodgkin's disease and other childhood cancers should be regularly evaluated. Results of these evaluations will be the basis for introducing new treatment protocols aimed of decreasing the incidence of late complications while maintaining or improving cure rates.
-
Comparative Study Clinical Trial
[Treatment of pain in patients after tonsillectomy].
The aim of the study was to evaluate post-operative pain in patients after tonsillectomy, treated with non-steroid anti-inflammatory and opioid drugs. A group of 57 patients aged from 16 to 53 years was examined. 32 of them were treated with ketoprofen (Ketonal, Lek) in a dose 100 mg, 3 times a day and the remaining 25 with tramadol hydrochloride (Tramal) in daily doses 150-200 mg. The numerical 0 to 10 (VAS) and 6-grade verbal scales were used to assess pain intensity. ⋯ In the course of the first few postoperative days, inflammation is aggravated due to infection of the wound in the throat and the latter mechanism alone may be insufficient. Effectiveness of either ketoprofen or tramadol in treatment of post-tonsillectomy pain is good but better in the case of tramadol. Patients must be informed in advance about a possibility of more intense pain a few days after tonsillectomy, in order to avoid unjustified fear.
-
Comparative Study
[Antibodies against heat shock proteins (HSP) in children with chronic renal failure (CRF)--preliminary results].
Current data suggest the role of autoimmune reactions in the pathogenesis of cardiovascular complications in CRF patients. Elevated levels of anti-Hsp autoantibodies (anti-Hsp60, anti-Hsp70) have been described in adults with atherosclerotic lesions and cardiovascular events. The aim of the study was to evaluate the levels of anti-Hsp60 and anti-Hsp70 in sera of CRF children. Serum uric acid, lipid profile, erythrocyte sedimentation rate (ESR) and hsCRP were also estimated. ⋯ Preliminary results point at relations between anti-Hsp70, markers of chronic inflammation (ESR) and atherosclerotic risk (uric acid, cholesterol) in CRF children.
-
The occurrence of the disturbances of oropharyngeal phases of swallowing in Amyotrophic Lateral Sclerosis (ALS) patients has been well documented. ⋯ This study reveal the occurrence of disturbances of the oesophageal phase of swallowing in ALS patients with dysphagia.
-
Clinical Trial
[Mycophenolate mofetil in treatment of childhood nephrotic syndrome--preliminary report].
The management of nephrotic syndrome (NS) in children remains a clinical challenge for pediatricians and pediatric nephrologists. Especially, the treatment of patients with steroid-resistant (SR) and steroid-dependent (SD) nephrotic syndrome, because they are at risk for developing complications from prolonged exposure to steroids, CsA and alkylating agents. Mycophenolate mofetil (MMF) is a selective and reversible inhibitor of inosine monophosphate dehydrogenase used above all in transplantology and recently also in patients with nephrotic syndrome. ⋯ The initial clinical observation of MMF treatment in nephrotic patients shows its best effect in the group of patients with steroid-dependent NS. MMF can safely be used in children with NS. The introduction of MMF allows for reduction of other chronically used medications, especially CsA and steroids.