Revista brasileira de anestesiologia
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Rev Bras Anestesiol · Mar 2008
In vitro and in vivo neuromuscular effects of atracurium and rocuronium in rats treated with carbamazepine for seven days.
This experimental study investigated the in vitro and in vivo neuromuscular blockade of rocuronium and atracurium in rats treated with carbamazepine and determined the concentration of cytochrome P450 and b5 reductase in hepatic microsomes. ⋯ Seven-day treatment with carbamazepine did not change the neuromuscular blockade produce by atracurium, but altered the in vitro effects of rocuronium. The duration of the treatment was not enough to cause enzymatic induction and decrease the sensitivity to rocuronium.