Casopís lékar̆ů c̆eských
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Casopís lékar̆ů c̆eských · Jan 2005
Review[Treatment of the unresectable non small cell lung carcinoma].
In recent years, treatment of the locally advanced unresectable Non Small Cell Lung Cancer (NSCLC) has evolved from the radiotherapy alone to sequential therapy settings with induction chemotherapy followed by radiotherapy. During recent years, concomitant chemoradiotherapy has become the standard treatment for these patients. The addition of chemotherapy during the course of radiotherapy provides better locoregional control of the disease by killing the radioresistant cells, inhibition of the reparation processes in the sublethally damaged cells and accumulation of the cells in the G2/M phase, when the cells are sensitive to radiation. ⋯ When comparing survival time by meta-analysis, significantly longer survival time of the patients treated with gemcitabine combination was found in comparison with other treatment. Similarly, the progression-free survival is significantly longer in the patients treated with gemcitabine containing regimen. This data has proven good clinical efficacy of gemcitabine in the first-line therapy of advanced NSCLC.
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Interstitial cystitis is a chronic, non-bacterial inflammatory disorder of the wall of the urinary bladder and it manifests with very painful symptoms. Initially it can resemble a bacterial inflammation of the urinary bladder. ⋯ Increasing incidence, chronicity of this disorder and specific treatment leads to the reinterpretation of the chronic inflammation of the urinary tract diagnosed in the past and to the modification of the treatment of these patients. Because of the polymorphic difficulties and the psychosomatic manifestations, IC can lead to invalidity of the patient.
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Casopís lékar̆ů c̆eských · Jan 2005
[Telephone hotlines as a part of complex services for tobacco dependence treatment].
Telephone quitlines for smoking cessation should be included into the available tobacco dependence treatment and should be included into smoking cessation guidelines. Telephone quitlines does not mean only the help to the calling smoker, but also can increase the number of quit attempts in the general population. ⋯ Quitlines are economically effective, although the most expensive form - individual counselling - should be reserved for those really willing to stop. Quitlines should be given governmental financial support (compared to other medical interventions, any smoking cessation treatment is economically more cost effective).
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Casopís lékar̆ů c̆eských · Jan 2005
[Comparison of the prevalence of non-invasive risk markers of the sudden cardiac death in patients treated by thrombolysis and by percutaneous transluminal coronary angioplasty].
Myocardial infarction survivors may develop a higher risk of sudden cardiac death. The risk markers: left ventricular ejection fraction, ventricular premature beats, late potentials on averaged ECG, baroreflex sensitivity and heart rate variability are used as non-invasive stratification markers. ⋯ Patients treated by primary PTCA had significantly lower occurrence of premature ventricular beats and pathological parameters of the heart rate variability.
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Casopís lékar̆ů c̆eských · Jan 2005
Historical Article[34,450 days of cardiac surgery in the Czech Republic].
Professor Karel Maydl was born in Rokytnice nad Jizerou, where his father was employed at the local court. Czech cardio-surgery was born with the first successful treatment of the stab in the heart, which was done by professor Rychlík in 1910. The next few years the cardio-surgery was represented only by occasional treatment of heart injury. ⋯ At the end Professor Maydl, who died for heart failure, is quoted, why he himself had to be stroked by the disease, which is not possible to treat with the knife. In the 100 years since that it is possible to evaluate that in ICEM 283 medical doctors have been treated for the heart disease and results of their operations were Berger than in standard population. It reproves the bad record of doctors to be bad patients.