Journal of research in pharmacy practice
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J Res Pharm Pract
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Addition of vasoconstrictors to local anesthesia results in prolonged pain control. However, associated soft-tissue anesthesia (STA) of the lips and tongue typically lasts 3-5 hours which is longer than required time for pain control after routine dental procedures can lead to inadvertent biting of the soft tissue, particularly in children. The present study aimed to evaluate phentolamine mesylate (PM) effect on duration of STA and incidence of soft-tissue trauma after mandibular block injection. ⋯ PM can be considered as a safe and effective drug for reduction of reversal time of STA after dental procedures.