Gan to kagaku ryoho. Cancer & chemotherapy
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Gan To Kagaku Ryoho · Aug 1992
Multicenter Study Clinical Trial[Examination of anti-emetic effect and safety of multiple intravenous doses of ondansetron in patients receiving nonplatinum anti-cancer drugs].
Anti-emetic effects, safety and usefulness of Ondansetron given intravenously at 4 mg once daily for consecutive 3-5 days were investigated against nausea and emesis induced by non-platinum anticancer drugs. Efficacy rates in control of nausea and emesis were 59% (20/34 cases) and 68% (23/34 cases), respectively. ⋯ Adverse events (headache and constipation) were observed in 1 case and abnormal change in clinical laboratory findings (increase in eosinophil count) in another case. Out of 42 cases in which safety was evaluated, 41 (98%) cases were assessed as "no problem in safety." However, one case with side effect was assessed as a "Minor problem in safety." From the above, it was confirmed that Ondansetron injection exerted excellent inhibitory effects against nausea and emesis induced by non-platinum anti-cancer drugs, and this drug was a highly safe and useful anti-emetic.
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Gan To Kagaku Ryoho · Aug 1992
[Therapeutic results of intra-arterial infusion chemotherapy using an implantable reservoir on metastatic liver tumors].
Forty-four patients with unresectable liver tumors including 25 colorectal cancers, 7 gastric cancers, 6 breast cancer, and 6 other diseases, were treated by intra-arterial infusion chemotherapy using an implantable reservoir. The catheter was placed in hepatic artery via left subclavian artery or by direct insertion at laparotomy. Adriamycin, epirubicin or cisplatin were administered intermittently. ⋯ Response was also validated by survival time and changes in CEA. In a few patients, metastatic lesions could be resected after this treatment. Our results indicate that in combination with an aggressive surgical procedure, this treatment may improve the prognosis of patients with metastatic liver tumors.