Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2006
Correction of erroneous and ectopic beats using a point process adaptive algorithm.
We present a new R-R interval correction procedure based on a point process model of the human heart beat. The algorithm combines an adaptive point process filter with a set of conditions on the probability of having a beat according to the model. This framework allows for correction of ectopic and erroneously detected beats in an on-line fashion, simultaneous with computation of instantaneous estimates of heart rate and heart rate variability. Results demonstrate the efficacy of the method, and show new heart rate and heart rate variability dynamics corrected for artifacts introduced by incorrect and/or irregular R-R intervals.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2006
Optimizing deep brain stimulation parameter selection with detailed models of the electrode-tissue interface.
Deep brain stimulation (DBS) is an established clinical therapy for the treatment of Parkinson's disease. However, selecting stimulation parameters for maximal clinical benefit can be a difficult and time consuming process that typically requires a highly trained and experienced individual to achieve acceptable results. To address this limitation we developed a Windows-based software package (StimExplorer) intended to aid the clinical implementation of DBS technology. ⋯ The software then provides theoretically optimal stimulation parameter suggestions, intended to represent the start point for clinical programming of the DBS device. The software system is packaged into a clinician-friendly graphical user interface that allows for interactive 3D visualization. The goals of the StimExplorer system are to educate clinicians on the impact of stimulation parameter manipulation, and improve the customization of DBS to individual patients.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2006
An integrated system supporting training in medical and administrative decision making in the emergency department.
The aim of the present project was the development of an integrated computer-based system supporting training in medical and administrative decision making in the Emergency Department. The system comprises of, first, a module supporting on-line acquaintance with Emergency Medical Guidelines, second, a vital-signs monitoring and processing module, and finally an administrative module organizing the most relevant facts about a patient's health status in compliance with the ASTM E2369-0 Standard Specification for Continuity of Care Record, in order to be employed after discharge from the Emergency Care to a hospital ward or to homecare.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2006
An evaluation of a PTT-based method for noninvasive and cuffless estimation of arterial blood pressure.
The aim of this study is to determine if a noninvasive and cuffless blood pressure (BP) estimation method using pulse transit time (PTT) can accurately track the changes in BP after a treadmill exercise. Experiments were conducted on 12 healthy subjects, who were directed to run on a treadmill at 10 kph for 4 minutes. For each subject, 13 trials were recorded in total, including 11 trials obtained immediately after exercise and during the 60-minute recovery period. ⋯ Both PTT-based device and Finometer were calibrated initially and Finometer calibration was also performed after exercise to the sphygmomanometer. Experimental results showed that there was only occasional discrepancy between BPs measured by Finometer and PTT-based device during the recovery period, i.e., at 5 minutes after exercise (p=0.008 for systolic BP and p=0.03 for diastolic BP). At all other post exercise time spots there were no significant differences between BPs measured by Finometer and PTT-based device.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2006
High rate shear insult delivered to cortical neurons produces heterogeneous membrane permeability alterations.
Traumatic brain injury (TBI) occurs when brain tissue is subjected to stresses and strains at high rates and magnitudes, yet the mechanisms of injury and cellular thresholds are not well understood. The events that occur at the time of and immediately after an insult are hypothesized to initiate cell dysfunction or death following a critical cell strain and strain rate. We analyzed neuronal plasma membrane disruption in two in vitro injury models-fluid shear stress delivered to planar cultures and shear strain induction of 3-D neural cultures. ⋯ Furthermore, increased membrane permeability led to increases in electrophysiological disturbance. Specifically, cells that exhibited increased membrane permeability did not fire random action potentials, in contrast to neighboring cells that had intact plasma membranes. This approach provides an experimental framework to investigate injury tolerance criteria as well as mechanistically driven therapeutic strategies.