Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2010
Non lineal respiratory systems mechanics simulation of acute respiratory distress syndrome during mechanical ventilation.
Model and simulation of biological systems help to better understand these systems. In ICUs patients often reach a complex situation where supportive maneuvers require special expertise. ⋯ This work presents a model which can be simulated and use to help in training of physicians and respiratory therapists to analyze the respiratory mechanics in this kind of patients. We validated the model in 2 ARDS patients.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2010
Merging PK/PD information in a minimally parameterized model of the neuromuscular blockade.
A recursive system identification algorithm that merges PK/PD information in a minimally parameterized Wiener model for the NMB level is presented. The results show that the coupling between one parameter from the linear block and one from the static nonlinearity is advantageous, when evaluated on a database of 60 real collected NMB cases.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2010
Steering deep brain stimulation fields using a high resolution electrode array.
Deep brain stimulation (DBS) therapy relies on electrical stimulation of neuronal elements in small brain targets. However, the lack of fine spatial control over field distributions in current systems implies that stimulation easily spreads into adjacent structures that may induce adverse side-effects. ⋯ Our computational analysis demonstrates that the DBS-array is capable of accurately displacing activation volumes with sub-millimeter precision. Our findings demonstrate that future systems for DBS therapy may provide for more accurate target coverage than currently available systems achieve.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2010
Theoretical simulation of the dual-heat-flux method in deep body temperature measurements.
Deep body temperature reveals individual physiological states, and is important in patient monitoring and chronobiological studies. An innovative dual-heat-flux method has been shown experimentally to be competitive with the conventional zero-heat-flow method in its performance, in terms of measurement accuracy and step response to changes in the deep temperature. ⋯ The corresponding depth of the estimated temperature in the skin and subcutaneous tissue layer is consistent when using the dual-heat-flux probe. Insights in improving the performance of the dual-heat-flux method were discussed for further studies of dual-heat-flux probes, taking into account structural and geometric considerations.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2010
Robust closed-loop control of propofol administration using WAVCNS index as the controlled variable.
This paper presents a robust closed-loop strategy for control of depth of hypnosis. The proposed method regulates the electroencephalogram (EEG)-derived WAVCNS index as a hypnosis measure by manipulating intravenous propofol administration. ⋯ This closed-loop control was evaluated using simulated surgical procedures in 44 patient models whose PK and PD were identified from real clinical data. The controller can deliver consistent and acceptable closed-loop induction and maintenance phase responses for patients with wide-ranging PK and PD differences.