Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Prediction of extubation failure for neonates with respiratory distress syndrome using the MIMIC-II clinical database.
Extubation failure (EF) is an ongoing problem in the neonatal intensive care unit (NICU). Nearly 25% of neonates fail their first extubation attempt, requiring re-intubations that are associated with risk factors and financial costs. ⋯ From an initial list of 57 candidate features, our machine learning approach narrowed down to six features useful for building an EF prediction model: monocyte cell count, rapid shallow breathing index, fraction of inspired oxygen (FiO(2)), heart rate, PaO(2)/FiO(2) ratio where PaO(2) is the partial pressure of oxygen in arterial blood, and work of breathing index. Algorithm performance had an area under the receiver operating characteristic curve (AUC) of 0.871 and sensitivity of 70.1% at 90% specificity.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Relaxofon: a neuromuscular blockade monitor for patients under general anesthesia.
Anesthesia consists of three components: unconsciousness, analgesia and neuromuscular blockade (NMB). A specific drug is administered by the anesthesiologist to control these different components. In this paper we propose a new system for monitoring the neuromuscular blockade in anesthesized patients during surgery. ⋯ Finally, we calculated the Pearson correlation coefficient to measure the linear dependence between the two methods. Automatic Train-of-Four ratio calculations using this system showed very good agreement with manual calculations. Results from this work may ultimately lead to integration of NMB monitoring to an automated closed-loop anesthesia system.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Assessing traumatic brain injuries using EEG power spectral analysis and instantaneous phase.
Although mild traumatic brain injury (mTBI) occurs commonly, little is known about how multiple mTBI incidents accumulate over time to produce serious morbidity or how the extent of injury can be quantified. This work presents a rat model that uses deceleration-induced brain trauma and an implantable EEG system for recording injury-induced changes in brain activity. ⋯ We found that in different frequency bands, both EEG power spectra and the instantaneous phases of the two EEG channels before the impact were different from those measured after the impact. This study shows that EEG analysis can be used as a tool to identify and assess brain related injuries.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Effect of anesthesia on spontaneous activity and evoked potentials of the cerebellar cortex.
Cerebellum is a highly organized structure with a crystalline morphology that has always intrigued neuroscientists. Much of the cerebellar research has been conducted in anesthetized animals, particularly using ketamine and xylazine combination. ⋯ The frequency contents of the spontaneous activity suggest that ketamine/xylazine anesthesia suppresses most of the components except those below 30 Hz. This preliminary study also showed that multi channels of cerebellar cortical activity can be recorded using flexible multi-electrode arrays in behaving animals, which is very challenging task with single microelectrodes.