The Journal of nutrition
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The Journal of nutrition · Feb 1998
Review Comparative StudyToxicity considerations when revising the Nordic nutrition recommendations.
The Nordic countries have issued common nutrition recommendations since 1980. In connection with the 3rd revision, a joint working group of nutritionists and toxicologists assessed the toxicology of selected trace elements. ⋯ The safety factors between the lowest intakes at which adverse effects had been reported and the suggested upper limits of intake were small. In the toxicological evaluation of upper safe intake levels of essential trace elements, interactions between trace elements as well as long-term exposure to moderately elevated trace element intakes have to be considered.
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The Journal of nutrition · Oct 1989
ReviewEffect of dietary fat composition on rat colon plasma membranes and fecal lipids.
The present study was designed to examine the effect of dietary fat composition on the structure of colon mucosal plasma membranes and fecal lipids. Rats were fed a purified diet containing 14% of either highly saturated fat (beef fat or butterfat) or highly polyunsaturated oil (safflower) in addition to 2% corn oil for 4 wk. Colon mucosal membranes were prepared and examined for lipid composition and protein pattern. ⋯ There was a 4-fold and 2-fold increase in fecal free fatty acids with feeding the beef fat and butterfat diets, respectively, compared to the safflower oil diet. Alterations in fecal bile acid and free fatty acid composition were also noticed with feeding saturated fatty acids. The results obtained suggest that feeding saturated fatty acids as the main source of fat in the diet could influence the structure of colon mucosa, and this could be mediated through fecal free fatty acids.