Biological psychiatry
The most recent articles from:
Biol. Psychiatry
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Biological psychiatry · Nov 2013
Stress in the adult rat exacerbates muscle pain induced by early-life stress.
Early-life stress and exposure to stressful stimuli play a major role in the development of chronic widespread pain in adults. However, how they interact in chronic pain syndromes remains unclear. ⋯ Early-life stress induces a persistent elevation of IL-6, hyperalgesia, and susceptibility to chronic muscle pain, which is unveiled by exposure to stress in adults. This probably depends on an interaction between adrenal catecholamines and proinflammatory cytokines acting at muscle nociceptor level.