La Revue du praticien
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Anti-CD20 monoclonal antibodies are currently used for non-Hodgkin's lymphoma treatment and Rituximab (MabThera) and ibritumomab-tiuxetan (Zevalin) currently approved for clinical use. Rituximab has improved survival of patients with follicular and diffuse large B cells lymphoma. ⋯ It is basically used associated with chemotherapy every three weeks and also as maintenance therapy for relapsed follicular lymphoma. A better understand of its mechanisms of action has allowed to develop new generation of monoclonal antibody currently tested in clinical trials.
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The diagnostic of lung cancer mainly relies on thoracic CT scan and bronchoscopic techniques. During the past decade, several improvements of these diagnostic tools have been made available, which aim to decrease the time to diagnosis and to simplify the initial staging approach. ⋯ The diagnostic of intra-mediastinal lymph nodes has been simplified by the use of endobronchial ultrasound--transbronchial needle aspiration. In the near future, these techniques should reduce the need for invasive surgical procedures during lung cancer staging.