Science
-
Figure 1 (p. 1061) of the report "Revival and identification of bacterial spores in 25- to 40-million-year-old Dominican amber" by R. J. ⋯ Borucki (19 May, p. 1060) was incorrect. The correct figure appears below. [See figure in the pdf file].
-
Specificity of protein kinases and phosphatases may be achieved through compartmentalization with preferred substrates. In neurons, adenosine 3', 5'-monophosphate (cAMP)-dependent protein kinase (PKA) is localized at postsynaptic densities by association of its regulatory subunit with an A kinase anchor protein, AKAP79. ⋯ The putative CaN-binding domain of AKAP79 is similar to that of the immunophilin FKBP-12, and AKAP79 inhibited CaN phosphatase activity. These results suggest that both PKA and CaN are targeted to subcellular sites by association with a common anchor protein and thereby regulate the phosphorylation state of key neuronal substrates.