Southern medical journal
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Anticonvulsant hypersensitivity syndrome (AHS) is a potentially life-threatening adverse drug reaction presenting with fever, skin eruptions, and internal organ involvement. We describe a case of AHS with fulminant hepatitis that occurred two weeks after introduction of lamotrigine in a 40-year-old female patient with a recently diagnosed bipolar disorder, no pre-existent systemic organ involvement, and no other medication. ⋯ The patient had favorable evolution with cessation of lamotrigine and supportive treatment. This report suggests that AHS with fulminant hepatitis may occur idiosyncratically, independent of dosage, titration and comedication with other potentially hepatotoxic drugs.
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Southern medical journal · Jan 2009
Letter Case ReportsPneumomediastinum in a 21-year-old female with lupus.
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Southern medical journal · Dec 2008
Comparative StudyPediatricians are more supportive of the human papillomavirus vaccine than the general public.
The purpose of this study was to determine pediatricians' attitudes about the human papillomavirus (HPV) vaccine and to compare their attitudes with those expressed by the general public. ⋯ Pediatricians are much more supportive of HPV vaccination than the general public. Pediatricians should be aware of these differences when counseling patients and their families.
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Southern medical journal · Dec 2008
Understanding and identifying bias and confounding in the medical literature.
Bias and confounding are types of error that may be encountered in the collection, analysis, or interpretation of research data. Bias and confounding may result in erroneous research conclusions with adverse consequences for patients and health care providers. In this article, we provide clinician-friendly descriptions and examples of bias (including surveillance, information, selection, lead, length, and publication) and confounding. The purpose of the article is to help clinicians to recognize two important sources of error in research and in turn to help clinicians to assess the validity and generalizability of a research report.