Southern medical journal
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Southern medical journal · Jan 2008
Historical ArticleLooking into the future of cell-based therapy.
Recent research points to the future of regenerative medicine. In the past year, a handful of research groups have demonstrated that mature, adult cells could be "reprogrammed" to a very primitive, embryonic state via the forced expression of four genes (Oct-3/4, c-Myc, Klf4, and Sox2). ⋯ While the reprogramming of human fibroblasts into iPS cells remains to be seen, it is nevertheless difficult to overstate the value that this new research contributes to the field of regenerative medicine and its academic relative developmental biology. Herein, we attempt to bring these monumental works into greater focus and comment on how they work to shape the future of cellular therapies.
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Southern medical journal · Jan 2008
Comparative StudyGastrointestinal tract bleeding in intellectually disabled adults.
Gastrointestinal (GI) tract bleeding in intellectually disabled (ID) individuals presents peculiar diagnostic and management difficulties. This study details the experience of a tertiary referral teaching hospital in Central Saudi Arabia in the management of GI bleeding necessitating admission in ID adults. ⋯ Bleeding GERD remained the most common etiology of upper GI bleeding necessitating admission. Endoscopy is the mainstay in diagnosis and initial management of ID patients. Continued surveillance endoscopy is recommended for early diagnosis of Barrett changes. Bleeding from developmental malformations may have association with intellectual disability.
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Southern medical journal · Jan 2008
Mounier-Kuhn syndrome: report of 8 cases of tracheobronchomegaly with associated complications.
Mounier-Kuhn syndrome is a rare congenital abnormality characterized by atrophy or absence of elastic fibers and thinning of smooth muscle layer in the trachea and main bronchi. These airways are thus flaccid and markedly dilated on inspiration and collapsed on expiration. First- to fourth-order bronchi are affected. ⋯ Eight cases of tracheobronchomegaly with its associated complications are reported. Computed tomography scan of the chest was used for the diagnosis of tracheobronchomegaly. Treatment is mainly supportive with chest physiotherapy and antibiotics; however, there are a few reported cases where insertion of a tracheal stent resulted in some success.
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Southern medical journal · Nov 2007
Association of poverty with sudden infant death syndrome in metropolitan counties of the United States in the years 1990 and 2000.
Sudden infant death syndrome (SIDS) has been associated with poverty indirectly in the United States with the use of vital statistics data by using proxies of socioeconomic status such as maternal education. ⋯ There is a significant association between poverty and SIDS at the metropolitan county level for NHB and NHW. Hispanics do not demonstrate this association.
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Southern medical journal · Nov 2007
Why are fewer medical students in Florida choosing obstetrics and gynecology?
To determine why there has been a decrease in the amount of applicants to Florida-based obstetrics and gynecology (OB/GYN) residency programs, and how this has been affected by the current medical liability climate. ⋯ There is a subgroup of students in Florida who were initially interested in OB/GYN but may have been deterred by current medical liability issues. Florida is a state known as being in a professional liability crisis and this survey demonstrates evidence that this has adversely affected students' decisions to pursue OB/GYN.