Southern medical journal
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Southern medical journal · May 2004
Randomized Controlled Trial Comparative Study Clinical TrialSedation during mechanical ventilation in infants and children: dexmedetomidine versus midazolam.
We sought to compare the efficacy of midazolam versus dexmedetomidine for sedation during mechanical ventilation in infants and children. ⋯ At a dose of 0.25 microg/kg/h, dexmedetomidine was approximately equivalent to midazolam at 0.22 mg/kg/h. At 0.5 microg/kg/h, dexmedetomidine provided more effective sedation as demonstrated by the need for fewer bolus doses of morphine, a decrease in the 24-hour requirements for supplemental morphine, as well as a decrease in the total number of assessment points with a Ramsay score of 1 (inadequate sedation) and the number of patients who had a Ramsay score of 1.
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Southern medical journal · Apr 2004
Randomized Controlled Trial Comparative Study Clinical TrialIncidence of postdural puncture headache and backache, and success rate of dural puncture: comparison of two spinal needle designs.
The goal of this randomized study was to compare the incidence of postdural puncture headache (PDPH) and postdural puncture backache (PDPB), and the success rate between two small-gauge spinal needle designs used in women undergoing subarachnoid block anesthesia. ⋯ The low complication and failure rates make these two types of smaller size spinal needle design good candidates for dural puncture procedures, such as spinal anesthesia, diagnostic lumbar punctures, and myelograms.
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Southern medical journal · Jan 2004
Randomized Controlled Trial Clinical TrialSex differences in analgesia: a randomized trial of mu versus kappa opioid agonists.
We sought to evaluate whether there is a sex difference in the analgesic response to mu versus kappa opioids in the management of acute moderate to severe pain of injury in the emergency department. ⋯ Females had better pain scores with butorphanol than morphine at 60 minutes.
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Southern medical journal · May 2003
Randomized Controlled Trial Comparative Study Clinical TrialWarmed versus room temperature saline for laceration irrigation: a randomized clinical trial.
Patient comfort is an important part of laceration repair. ⋯ Warmed saline was more comfortable and soothing than room temperature saline as a wound irrigant among patients with linear lacerations.
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Southern medical journal · May 2001
Randomized Controlled Trial Clinical TrialNew polyethylene glycol laxative for treatment of constipation in adults: a randomized, double-blind, placebo-controlled study.
This study evaluated the safety and effectiveness of a new polyethylene glycol (PEG) laxative (MiraLax, Braintree Laboratories Inc, Braintree, Mass) in 23 patients reporting a history of constipation. ⋯ Daily therapy with 17 g of PEG laxative for 14 days resulted in a significant improvement in bowel movement frequency in constipated patients relative to placebo by the second week of treatment.