Medizinische Monatsschrift für Pharmazeuten
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Med Monatsschr Pharm · Nov 2015
Case Reports[Multimodal pain management in a patient with atypical cervicogenic headache].
A 45-year-old patient presented with an eight-year history of persistent unilateral headache associated with recurrent episodes of ipsilateral conjunctival injections, eyelid edema and ptosis. Prior ineffective pharmacological treatment strategies included tramadol, non-steroidal anti-inflammatory drugs and triptans. ⋯ A multimodal treatment strategy (physical therapy, nerve blockade, pharmacological treatment) was chosen and an emphasis was put on optimizing pharmacological pain relief using the opioid analgesic tapentadol and the tricyclic antidepressant amitriptyline as an adjuvant analgesic. Importantly, the patient reported a substantial and consistent pain reduction and considerable quality of life improvement during implementation of the treatment regimen.
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During the last decade, the therapeutic management of hepatitis C virus (HCV) infection has changed dramatically. Due to the recent approval of several directly acting antiviral agents (DAAs) such as sofosbuvir, daclatasvir, or ledipasvir, HCV eradication is possible in the vast majority of HCV infected individuals by DAA combinations with or without pegylated interferon-α. This review summarized these exciting developments with a focus on current recommendations for the treatment of chronic hepatitis C.