Medizinische Monatsschrift für Pharmazeuten
-
Helicobacter pylori has an important role in the pathogenesis of peptic ulcer, adenocarcinoma of the stomach, lymphoma of the stomach and autoimmune gastritis. Furthermore Helicobacter pylori is involved in the development of symptoms in patients with dyspepsia. Guidelines of the German Society of Digestive Diseases (DGVS) and recommendations of the European Helicobacter Study Group (Maastricht-Consensus) exist for the diagnosis and treatment of Helicobacter pylori and were recently published in updated versions. The German approval and introduction of a new quadrupel eradication therapy for Helicobacter pylori infections is a good occasion to outline and discuss the current state of the art of diagnosis and treatment of Helicobacter pylori in Germany.
-
Med Monatsschr Pharm · Oct 2012
Review Guideline[Vaccinations in patients with autoimmune inflammatory rheumatic diseases--EULAR recommendations for pediatric and adult patients].
Since patients with autoimmune inflammatory rheumatic diseases are prone to infectious complications--on one hand due to the rheumatic disease itself, on the other hand due to the immunosuppressive therapy--vaccination is an essential tool to prevent these infectious complications. Although there exist several recommendations for the vaccination of immunocompromised patients, many questions still remain for the distinct clinical situations of patients with autoimmune inflammatory rheumatic diseases. ⋯ Therefore, EULAR (European League Against Rheumatism) assembled two expert panels to clarify as much of these clinical problems as possible. After extensive literature review and evidence grading, the expert panels published recommendations for the vaccination of adult and pediatric patients, which are outlined in this review article.
-
Med Monatsschr Pharm · Nov 2011
Review[Pregnant opioid addicted patients and additional drug intake. Part II: Comorbidity and their therapy].
The majority of opioid dependent patients suffer from various psychiatric and somatic comorbid diseases like mood and anxiety disorders, psychotic diseases, personality disorders, HIV infection, Hepatitis B and C. If medical treatment is needed, grouping active substances to FDA Pregnancy Categories (A, B, C, D or X) may be helpful. The majority of substances reported here only fulfill the FDA-categories C or D, which means that they could have teratogenic effects, but with probably different rank order. ⋯ In addition the specific drug treatment of HIV and hepatitis B during pregnancy is described. During childbirth HIV-infected patients should receive zidovudine intravenously to prevent vertical transmission. Co-infection with hepatitis C cannot be treated during pregnancy, since interferons are associated with a severe risk of fetal malformations and ribavirin has teratogenic effects; for this reason interferon therapy should be started after delivery.