Missouri medicine
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Most newborns with severe combined immunodeficiency (SCID) appear normal. Hematopoietic stem cell transplant within the first three months of life increases survival and decreases medical costs. Newborn screening measuring T cell receptor excision circles (TREC), a by product of T cell maturation, offers the opportunity for early diagnosis before infections and failure to thrive occur. The Secretary of Health and Human Services recently recommended addition of TREC to newborn screening, enabling prompt diagnosis and effective management of SCID.
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Although uncommon, "brain cancer" is one of the most feared diseases that afflict human beings. While still regarded as one of the most deadly forms of primary malignant brain neoplasm, recent advances in the treatment of Glioblastoma Multiforme (GBM) have offered new hope for patients, families and clinicians. In the first part of this two-part evidence-based review, we focused on the multidisciplinary advances that have established the current standard of care practice in the management of GBM. The second part discusses ongoing research efforts, both ongoing clinical trial efforts as well as some of the newer technologies that are forming the promise of the future.