Nihon Geka Gakkai zasshi
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Nihon Geka Gakkai zasshi · Jun 1988
[Effects of dopamine receptor agonists and antagonists on an experimental ulcer system induced by cysteamine in rats--dopaminergic mechanism vs pathogenesis of peptic ulceration].
The physiological roles of sympathetic nerve system in the stomach has been thought to be very important in the pathogenesis of peptic ulceration. The aim of this study was to examine the effects of dopamine receptor agonists and antagonists on gastric acid secretion and gastroduodenal ulcer formation induced by cysteamine injection in rats. Cysteamine was given by subcutaneous injection as 400mg/kg in doses. ⋯ As a result of acid output measured during infusion of dopamine alone or dopamine with domperidone in non-vagotomized or vagotomized rats, increasing effects of dopamine on acid output were depended on dopaminergic mechanism, and decreasing effects of dopamine on acid output were depended on dopaminergic mechanism in rami vagus. As a result of duodenal and gastric ulcer index, ulcerogenicity of cysteamine in the stomach was concerned with dopaminergic mechanism more than that of in the duodenum. These results suggested that the pathogenesis of experimental ulcer induced by cysteamine injection was depended on dopamine receptor in the stomach.
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The therapeutic goals for fluid replacement in 9 patients were studied. Five cases in sepsis, 2 in necrotizing pancreatitis and 2 in fat embolism were treated as dehydration or hypovolemia. Fluid replacement was performed with the view of obtaining the amelioration of circulation and urine output, even if CVP or PCWP had been elevated on admission. ⋯ Out of 9 patients, 8 were suffering from respiratory distress, however, 7 recovered by PEEP except for one refractory shock. High values of CVP or PCWP could be recognized even if in hypovolemic shock and/or septic shock. Maintenance of higher values (18-20 mmHg) in CVP and/or PCWP during fluid resuscitation might be recommended because adequate fluid resuscitation could sustain the renal function, and result in good outcome.
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Nihon Geka Gakkai zasshi · Jan 1987
[The effect of glucagon on hepatic blood flow and ICG excretion].
Loading of glucagon on mongrel dogs was performed and the following results were obtained: The effects of glucagon on hemodynamics were decrease in the vascular resistance and increase in the blood flow in the superior mesenteric artery. Therefore, the blood flow of the portal vein was also increased. In the hepatic artery, glucagon also decreased the vascular resistance, when the blood flow was initially increased and then decreased. ⋯ After simultaneous loading of glucagon and ICG on cirrhotic and control patients, accelerated excretion of ICG with time course was observed in control group. On the other hand, slightly accelerated excretion was seen in cirrhotics. It was suggested that simultaneous loading test of glucagon and ICG may be useful as a test for dynamic ability of hepatic circulation which can not be obtained by ICG loading test.
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Nihon Geka Gakkai zasshi · Jul 1986
[Measurement of the portal blood flow in man by continuous local thermodilution method: II. Portal hemodynamics before and after hepatectomy].
We found that measurements of portal blood flow by continuous thermodilution were highly reproducible even after hepatectomy. Our subjects numbered 59 in all: In these patients having diseases of the liver and biliary tract, we studied portal hemodynamics during percutaneous transhepatic portography. Of these, 37 underwent hepatectomy. ⋯ With this exception, in patients with major resections, portal venous flow per liver volume had increased after surgery and continued to increase. This was not true for patients with minor resections. Portal hemodynamics are important in the functioning and regeneration of the remaining liver, and it is necessary to understand and medically correct portal hemodynamics before and after hepatectomy.