Nihon Sanka Fujinka Gakkai zasshi
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Nippon Sanka Fujinka Gakkai Zasshi · Aug 1991
[Developmental sequence of fetal behavior and the functional development of the fetal central nervous system].
The development of central nervous system (CNS) is the latest among the various fetal organs and is on the way to mature even at birth. Because behavior is the phenotype of the CNS function, the behavioral pattern significantly changes with the developmental stage of CNS throughout the whole fetal period. The purpose of this study is to clarify the developmental sequence of fetal behavior and to discuss the functional development of the fetal CNS. ⋯ The other movements showed the respective patterns of the changes in the incidence. Secondly, animal experiments were performed to obtain the basic data on fetal behavior which could not be given by the ultrasonographic observation of human fetuses. Fetal goats were incubated under the physiological condition in artificial amniotic fluid by using extracorporeal membrane oxygenation (ECMO) system.(ABSTRACT TRUNCATED AT 250 WORDS)
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Nippon Sanka Fujinka Gakkai Zasshi · Oct 1989
Comparative Study[Umbilical blood-gas status at cesarean section for breech presentation: a comparison with vertex presentation].
Umbilical blood-gas status at elective cesarean section with oxygen inhalation for breech presentation (25 cases) was compared with that for vertex presentation (25 cases), so as to confirm the security of full-term breech fetuses delivered by cesarean section under spinal anesthesia. Umbilical arterial oxygen levels were significantly lower in the breech group (Mean PO2:18.9 mmHg; SO2:37.3%; Oxygen content:7.6 ml/dl). The number of hypoxemic fetuses was significantly higher in the breech group (the breech: 7; the vertex; 0). ⋯ The incidence of depression at 1 minute after delivery in the breech infants (24%) was significantly higher than that in the vertex infants (0%). It became obvious in the breech that as the interval between the uterine incision and delivery increased, umbilical arterial blood tended to acidosis and the 1 minute Apgar score decreased. Cesarean section for breech presentation requires sufficient and optimal incisions of the abdominal wall and uterus as well as a skillful manual delivery technique, because the fetus or neonate should be protected against asphyxia resulting from umbilical compression and prolonged delivery interval.
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Nippon Sanka Fujinka Gakkai Zasshi · Jan 1989
[New method for preventing spinal headache (prophylactic blood patch method)].
After spinal anesthesia, early ambulation frequently caused spinal headache. If the patient was discharged on the day of the operation, spinal headache occurred very frequently. With epidural anesthesia, if the dura was erroneously punctured with the needle, headache often occurred. ⋯ Epidural puncture was performed one spinal segment cephalad (A Method) or one spinal segment cauded (B Method) from the site of spinal puncture. The prophylactic Blood Patch Method was very effective in preventing spinal headache after the dural puncture. Especially B Method, in which blood was injected near the dural pore, was much more effective than A Method.
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Nippon Sanka Fujinka Gakkai Zasshi · Jul 1988
[Antiemetic efficacy of high-dose metoclopramide, diphenhydramine, methylprednisolone and diazepam on chemotherapy-induced emesis in gynecological malignancy].
The antiemetic efficacy of high-dose metoclopramide (MCP), diphenhydramine (DPH), methylprednisolone (MPL), and diazepam (DZP) was investigated in 40 gynecologic cancer patients for a total of 98 chemotherapy courses, treated with cisplatin (50 mg/m2). With MPL (500 mg i.v. x 2) plus DZP (5 mg i.m. x 2), no vomiting occurred in 0% and mild emesis (vomiting 1-2 times) occurred in 20% of 25 courses. ⋯ These results indicate that high-dose MCP plus DPH are effective in preventing cisplatin-induced vomiting. Furthermore, the antiemetic efficacy of MCP plus DPH (0-2 vomiting episodes: 45%) was significantly enhanced (p less than 0.05) by the combined use of MPL plus DZP (0-2 vomiting episodes: 76%).
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Nippon Sanka Fujinka Gakkai Zasshi · Nov 1987
[The prevention of CDDP-induced emesis with a combination regimen including metoclopramide, dexamethasone, droperidol and diphenhydramine].
The dose limiting factors of cisplatinum are nephrotoxicity and emesis. Nephrotoxicity has been reduced by hydration but nausea and vomiting caused by cisplatinum have led to refusal of potentially curative therapy by a number of patients. The prevention of nausea and vomiting by a combination of antiemetic drugs administered to ovarian patients receiving chemotherapy inducing (cisplatinum 50mg/m2, adriamycin 300 mg/m2, cyclophosphamide 300 mg/m2 and 5FU 350 mg/m2) was studied. the combination antiemetic drugs were metoclopramide (1mg/kg), dexamethasone (10mg/m2), droperidol (1mg/m2) and diphenhydramine (20mg/body). ⋯ Diphenhydramine was administered intramuscularly 30 minutes before and 5 hours after chemotherapy. No vomiting was noted in 82.6% (19/23) of cases, and no patient vomited more than four times. This combination regimen provided very good protection against cisplatinum induced emesis.