Zhonghua bing li xue za zhi Chinese journal of pathology
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Zhonghua Bing Li Xue Za Zhi · Sep 2012
[Mutations of KRAS and BRAF in Chinese patients with colorectal carcinoma: analyses of 966 cases].
To identify the mutation rate of KRAS and BRAF in Chinese patients with colorectal carcinoma (CRC), and to analyze the associations between KRAS/BRAF mutations and patients' clinicopathological characteristics. ⋯ In Chinese CRC patients, KRAS mutations are associated with gender, age, tumor differentiation and primary tumor sites, while BRAF mutation is only associated with tumor differentiation and primary tumor sites. The correlations between KRAS/BRAF mutations and patients' prognosis need further investigation.
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Zhonghua Bing Li Xue Za Zhi · Aug 2012
[Relevance of molecular alterations in histopathologic subtyping of lung adenocarcinoma based on 2011 International Multidisciplinary Lung Adenocarcinoma Classification].
To evaluate the relevance of molecular alterations and histopathological subtypes of lung adenocarcinoma according to 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Lung Adenocarcinoma Classification. ⋯ The new classification, combined with TTF-1 immunomarker, can help to predict the molecular alterations of EGFR and KRAS genes, but can not indicate the EML4-ALK fusion in lung adenocarcinoma. Lepidic, papillary, and micropapillary predominant adenocarcinomas with TTF-1 expression are closely related to the presence of EGFR mutation, and invasive mucinous adenocarcinoma, while colloid predominant adenocarcinoma without TTF-1 expression is closely related to the presence of KRAS mutation.
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Zhonghua Bing Li Xue Za Zhi · Aug 2012
[MicroRNA383 regulates expression of PRDX3 in human medulloblastomas].
To investigate the effects of microRNA-383 (miR-383) on PRDX3 gene expression, cell proliferation and apoptosis of human medulloblastma. ⋯ Compared with normal brain tissue, decreased expression of miR-383 but elevated expression of PRDX3 are medulloblastoma tumour and Daoy cell lines. Up-regulation of miR-383 knockdowns the expression of PRDX3, inhibits proliferation and promotes apoptosis of Daoy cells, leading to increased intracellular ROS and decreased levels of mitochondrial membrane potential.
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Zhonghua Bing Li Xue Za Zhi · Jun 2012
Comparative Study[Comparative analysis of cytopathologic and histopathologic diagnosis in the transbronchial needle aspiration specimens].
To study the cytopathologic features of transbronchial needle aspiration (TBNA) samples and to evaluate the role of cytopathology in the diagnosis and staging of lung carcinomas, as compared to histopathology. ⋯ Cytopathology of TBNA specimens is accurate and sensitive for diagnosing pulmonary carcinomas. In most cases, the lung carcinoma can be precisely typed. TBNA is useful for diagnosing and staging lung carcinomas.