Zhonghua bing li xue za zhi Chinese journal of pathology
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Zhonghua Bing Li Xue Za Zhi · Oct 2011
[Clinicopathologic features of calcifying fibrous tumor with reappraisal of its histogenesis].
To study the clinicopathologic features and histogenesis of calcifying fibrous tumor (CFT). ⋯ CFT has characteristic histopathologic manifestations and shows morphologic and immunohistochemical overlaps with known IgG4-related sclerosing diseases. It is possible that CFT may represent another example of IgG4-related diseases. It often runs a benign clinical course, with rare recurrence after surgical resection. Previous inflammation and trauma may be the precipitating factors of CFT.
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Zhonghua Bing Li Xue Za Zhi · Oct 2011
[Relationship between mutations of epidermal growth factor receptor gene and clinicopathologic features of non-small cell lung cancers].
To explore the relationship between the mutations of epidermal growth factor receptor (EGFR) gene and clinicopathological characteristics in patients with non-small cell lung cancers (NSCLC). ⋯ The detection rate of EGFR mutation is higher in Chinese patients, especially in non-smoking female patients with adenocarcinoma. Real-time PCR is a sensitive and accurate method to detect the mutations of EGFR gene and can therefore provide useful information for clinical treatment.
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Zhonghua Bing Li Xue Za Zhi · Oct 2011
[Detection of epidermal growth factor receptor gene mutations and its clinical significance in non-small cell lung cancers].
To investigate the detection technology and its clinical significance of the EGFR gene mutation in non-small cell lung cancer. ⋯ DNA direct sequencing method by PCR amplification is stable and reliable in detection of EGFR gene mutation in non-small cell lung cancer. It might provide a scientific basis for targeted therapy.
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Zhonghua Bing Li Xue Za Zhi · Oct 2011
[Relationship of epidermal growth factor receptor gene mutations, clinicopathologic features and prognosis in patients with non-small cell lung cancer].
To investigate epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 of patients with non-small cell lung cancer (NSCLC) and to analyze the relationship of EGFR mutations with clinicopathological features and prognosis. ⋯ EGFR mutations occur frequently in females, non-smokers and adenocarcinomas, bronchioloalveolar carcinomas, and adenosquamous carcinomas. The patients with EGFR mutations have better prognosis. The results may offer a practical approach to select the patients who may benefit from anti-EGFR target therapy.
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Zhonghua Bing Li Xue Za Zhi · Oct 2011
[Epidermal growth factor receptor gene mutations, amplification and clinicopathologic correlation in patients with lung cancer].
To investigate the clinicopathological features of patients with lung cancers associated with epidermal growth factor receptor (EGFR) gene amplification and/or mutations. ⋯ EGFR gene mutations occur more frequently in females, non-smokers and patients with adenocarcinoma subtype. A significant variation of the mutation types exits among the subtypes of adenocarcinoma. The presence of EGFR amplification appears not related to age, gender, histopathological types of lung cancer and subtypes of adenocarcinoma. There is a significant correlation between EGFR mutations and its gene amplification (P=0.0005), although with poor consistency.