International journal of clinical and experimental medicine
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This study is to test the effectiveness of fiber-optic-guided endotracheal suction catheter (visual sputum suctioning system or VSSS) in dog models. ⋯ Visual sputum suctioning system collected more sputum and caused less tracheal mucosa damage than conventional suctioning.
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Previous studies demonstrated that systemic administration of lidocaine could induce central nervous toxicities, including behavioral convulsion as well as cognitive and cellular injury. Ketamine, a general anesthetic, is commonly used as an adjuvant in regional anesthesia with combination of lidocaine. The present was designed to investigate the effects of ketamine in central nervous toxicities of lidocaine. ⋯ We conclude that both pre- and/or post-administration of ketamine could improve lidocaine induced convulsive behaviors. However, cognitive functions and pathology of neurons of these rats are further impaired, compared to the rats without ketamine. This result indicates that ketamine combined with lidocaine might be risky in regional anesthesia.
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The common intravenous anesthetic agent, propofol, is frequently reported to have negative inotropic and chronotropic effects. In the pediatric population, propofol is commonly used after inhalation induction to facilitate endotracheal intubation without the need for a neuromuscular blocking drug agent. In this setting, we have noted that propofol administration is commonly followed by tachycardia. The current study prospective evaluates heart rate and blood pressure changes following the administration of propofol to pediatric patients anesthetized with nitrous oxide (N2O) and sevoflurane. ⋯ Tachycardia following propofol administration occurs in approximately 50% of pediatric patients despite preceding inhalation induction and concurrent administration of N2O and sevoflurane. Future studies are needed to define the mechanism for this effect.
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The aim of this study was to explore the risk factors, clinical symptoms, hematological parameters, causative pathogen and antibiotic susceptibility of neonatal sepsis in a Chinese NICU. ⋯ PICC is a bigger risk factor for neonatal late-onset sepsis. Staphylococcus epidermidis was the leading pathogen present in neonatal sepsis in a tertiary maternal & child care hospital in southern China. Vancomycin, teicoplanin and linezolid may be the best choice to management of neonatal sepsis.