Muscles, ligaments and tendons journal
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Muscles Ligaments Tendons J · Jan 2014
Impact of local anaesthetics and needle calibres used for painless PRP injections on platelet functionality.
The platelet-rich plasma (PRP) is an autologous biotherapy commonly used for its healing properties. Once activated, platelets released a real "cocktail" of growth factor and cytokines implied in numerous regenerative processes. However the impact of medical practices associated to PRP therapeutic use on platelets functionality remains poorly known. ⋯ the use of local anaesthetics to prevent pain during PRP injections could compromise the therapeutic potential of PRP. These results suggest using carefully local anaesthetics or limiting their use as often is possible. To minimize injection pain, we recommend using 30 G needles. These data will lead to clinical recommendations for painless and controlled PRP injections.
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Muscles Ligaments Tendons J · Oct 2013
Muscle, Ligaments and Tendons Journal. Basic principles and recommendations in clinical and field science research.
The design, implementation, evaluation, interpretation and report of research is a key important for the science. The research required minimize the uncertainty, therefore we encourage all authors of respect how much can possible the contents in this official editorial also in order to stimulate interest and debate about constructive change in the use of statistics in our disciplines1,2. Authors are required to confirm that these standards and laws have been adhered to by formally citing this editorial within the methods section of their own manuscript.
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Muscles Ligaments Tendons J · Apr 2011
Single injection of platelet-rich plasma in a rat Achilles tendon tear model.
The purpose of this study was to determine the efficacy of platelet-rich plasma (PRP) 1-injection during an Achilles tendon rat tear model. 80 male adult imbreded rats (Wistar Kyoto), underwent under surgical tendon rupture. 40 Animal (PRP group rats) were given a local injection with 0,25 mL of PRP, and 40 animal (control group) were given the same quantity of control solution. The rats were sacrified at 1, 2, 4 and 6 weeks (each time point, 20 rats of the each group) after surgical tear and tendon tissue was analysed by macroscopic aspect, histology, immunostaining and Real Time (RT)-PCR to evaluate tissue repair. ⋯ Immunostaining and RT-PCR did not show any difference between PRP treated and untreated group. Based on these findings a single injection of PRP appear not useful for Achilles rat tendon tear.
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Muscles Ligaments Tendons J · Jan 2011
Evaluation of a novel topical essential oxygen oil for the treatment of pain in acute tendinopathy and sprains.
Topical analgesics may play an increasingly important role in managing acute and chronic pain as acetaminophen, NSAIDs, and opioid drugs come under heightened scrutiny. This article reviews studies about essential oxygen oil, a topical over-the-counter (OTC) analgesic new to the American market but available for many years in Europe. ⋯ Its mechanism of action is not understood and further study is warranted. Essential oxygen oil is safe and effective for the treatment of pain associated with many common conditions, including tendinopathy, arthritis, sprains, and others.