Klinicheskaia meditsina
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Klinicheskaia meditsina · Jan 2012
Comparative Study[Safety and efficacy of various modalities of antiplatelet prophylaxis of ischemic stroke in elderly patients with non-valvular atrial fibrillation].
We compared the efficacy and safety of warfarin, dabigartan, and clopidogrel used to prevent tromboembolism in 210 elderly patients with non-valvular atrial fibrillation depending on the age. In patients aged 65--74 yr treatment with dabigartan (110 mg twice daily) for 6 months was associated with ischemic stroke as frequently as warfarin therapy but less frequently than with severe hemorrhages (4.4 vs. 27.7%, p < 0.05). ⋯ There were no differences in the frequency of thromboembolic and hemorrhagic complications in 75-80 year-old patients given the three medications. It is concluded that dabigartan and clopidorgel may be regarded as a good alternative to warfarin for anti-platelet treatment of 65-74 year-old patients with non-valvular atrial fibrillation.
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Klinicheskaia meditsina · Jan 2012
Case Reports[Successful rituximab therapy of HCV-cryoglobulinemic vasculitis with severe ulcerative and necrotic lesions of the skin].
This clinical observation demonstrates successful rituximab therapy of HCV-cryoglobulinemic vasculitis with severe ulcerative and necrotic lesions of the skin on the lower extremities. Vasculitis recurred 3 years after the persistent virological response had been achieved and complete clinical remission resulted from antiviral therapy. Possible causes of vasculitis relapses in the absence of HCV viremia are discussed with reference to the difficulties encountered in managing this condition.
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Klinicheskaia meditsina · Jan 2012
Biography Historical Article[Professional and ethical views of the physician humanist F.P.Gaaz].
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Klinicheskaia meditsina · Jan 2012
[The influence of smoking and occupational factors on the development of chronic obstructive pulmonary disease in oil industry workers].
The influence of smoking and occupational factors on the development of chronic obstructive pulmonary disease (COPD) in employees of a sea oil and gas company is considered. The primary role of smoking in pathogenesis of COPD is confirmed Direct and indirect influence of smoking is enhanced by occupational and climatic factors leading to the development of persistent disturbances of ventilation.
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Klinicheskaia meditsina · Jan 2012
Biography Historical Article[The contribution of Botkins' medical dynasty to national medicine].