Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk
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Vestn. Akad. Med. Nauk SSSR · Jan 2012
Review[Chronic pain: medico-biologic and sotsio-economic aspects].
In this article the role of neurobiological, psychological and social factors in pathogenesis of chronic pain is analyzed. The chronic pain is considered not as a symptom of damage of tissue and as independent illness due to non-adequate neuroplasticity of systems involved into regulation of pain sensitivity. The major role in development and maintenance of chronic pain is devoted to the primary genetically determined and/or secondary disturbance of interaction between nociceptive and antinociceptive systems at various levels--from peripheral neuron to central structures--that provides pain perception and painful behaviour development.
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Vestn. Akad. Med. Nauk SSSR · Jan 2012
Review[Prevention of tuberculosis: current approaches to development of vaccines].
This review is focused on recent advances in development of new vaccines for the prevention of tuberculosis. The main reasons for lack of BCG vaccine efficacy in different populations and geographic regions are presented. Design of new vaccines based on live modified strains of Mycobacterium bovis BCG, attenuated strains of Mycobacterium tuberculosis, recombinant proteins and viral vectors is considered in the specific examples. The usage of the heterologous "prime-boost" vaccination strategy against tuberculosis is discussed.
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Vestn. Akad. Med. Nauk SSSR · Jan 2012
Review[The application of nuclear medicine imaging in neurology, neurosurgery and psychiatry].
Analysis of use of nuclear medicine imaging (positron emission tomography and single photon emission computed tomography) in diagnosis, differential diagnosis and evaluation of treatment efficacy of central nervous system diseases is presented in this review. The possibility of radionuclide imaging techniques in different variants of dementia, Parkinson's disease, brain tumors is demonstrated on the basis of personal authors experience and recent literature data. Results of PET application in evaluating of the effecacy of stereotactic interventions in patients with anxiety obsessive disorders are also described in the review.
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Vestn. Akad. Med. Nauk SSSR · Jan 2009
Review[Improvement of higher medical education via the system of quality specialist training].
Development of the system of management of quality specialist training in the Kraysnoysrsk State Medical Academy allowed to optimize administration and academic process, create conditions for introduction of innovative technologies in educational, research, and clinico-diagnostic activities for the purpose of their standardization and realization of managerial decisions. The new system promotes organization of administrative and educational work of the Academy in line with leading trends of regional development, stimulates creativity and strategic planning.
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The elevation of body temperature during fever reaction and endogenous antipyretic effect reflects the existing balance between 2 components directed to the maximal positive use of the fever effects and simultaneous prevention of their side effects. The mechanisms involved in the control of balance between factors known as the fever triggers and endogenous antipyretic factors. The possible mechanisms of action of various endogenous antipyretic system components (glucocorticoids, neuropeptides, cytokines etc.) capable to regulate the duration and quantity of fever reaction are discussed in this review.