The journal of allergy and clinical immunology. In practice
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J Allergy Clin Immunol Pract · Sep 2017
The Importance of Prolonged Provocation in Drug Allergy - Results From a Danish Allergy Clinic.
Drug provocation is the "Gold Standard" in drug allergy investigation. Recent studies suggest that a negative drug provocation on first dose should be followed by a prolonged provocation over several days. ⋯ Only 11.0% of the provocations were positive. Importantly, only 1 of 5 patients tested positive on the first dose, indicating that prolonged exposure should always be considered when drug provocation is included in allergy investigations. Most provocations were with penicillins, reflecting the pattern of antibiotic use in Denmark, which differs from that in other countries, especially outside Northern Europe.
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J Allergy Clin Immunol Pract · Sep 2017
Neutrophilic Steroid-Refractory Recurrent Wheeze and Eosinophilic Steroid-Refractory Asthma in Children.
Little is known about inflammatory pathways of severe recurrent wheeze in preschool children and severe asthma in children. ⋯ Inflammation pathway of asthma and recurrent wheeze are related to eosinophil cells in older children and neutrophil cells in younger children. These results could improve personalized treatments.