The journal of allergy and clinical immunology. In practice
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J Allergy Clin Immunol Pract · Nov 2017
Multicenter StudyTreatment Effect and Safety of Icatibant in Pediatric Patients with Hereditary Angioedema.
Clinical manifestations of hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) usually begin in childhood, often intensifying during puberty. Currently there are insufficient efficacy/safety data for HAE therapies in children and adolescents due to the small number of pediatric patients enrolled in studies. ⋯ Symptom relief was rapid, and a single icatibant injection in pediatric patients with C1-INH-HAE was well tolerated (ClinicalTrials.gov identifier, NCT01386658).
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J Allergy Clin Immunol Pract · Nov 2017
Randomized Controlled TrialSafety Review of 5-Grass Pollen Tablet from Pooled Data of Clinical Trials.
The 5-grass pollen sublingual tablet has been approved for the treatment of grass pollen-induced allergic rhinoconjunctivitis in subjects with or without intermittent asthma. ⋯ The pooled analysis in 1,514 subjects from 8 clinical studies demonstrates that the 5-grass pollen sublingual tablet has a similar good safety profile in adult and pediatric patients with or without mild, intermittent asthma.
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J Allergy Clin Immunol Pract · Sep 2017
Temporal Trends in Epinephrine Dispensing and Allergy/Immunology Follow-up Among Emergency Department Anaphylaxis Patients in the United States, 2005-2014.
Anaphylaxis is a potentially life-threatening allergic reaction; measures including prescription of an epinephrine autoinjector (EAI) and allergy/immunology (A/I) follow-up may prevent future morbidity. ⋯ Over the past decade, rates of EAI dispensing and A/I follow-up after an ED visit for anaphylaxis have remained low, suggesting that patients may not be prepared to manage future episodes.
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J Allergy Clin Immunol Pract · Sep 2017
Diagnostic Accuracy of Inflammatory Markers for Diagnosing Occupational Asthma.
The assessment of airway responsiveness and inflammation is key to the investigation of occupational asthma (OA). ⋯ Blood eosinophil counts do not appear to be an effective aid for diagnosing OA. The performance of both sputum cell count analysis and a methacholine challenge before and after exposure to the offending agent may represent an effective alternative in diagnosing OA when SICs are unavailable.
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J Allergy Clin Immunol Pract · Sep 2017
Randomized Trial of Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Upper Airway Angioedema.
Upper airway angioedema is a rare, unpredictable, and at times life-threatening adverse effect of angiotensin-converting enzyme inhibitors (ACE-Is) with no existing effective pharmacologic treatment. Icatibant is a bradykinin B2 receptor antagonist that may be beneficial in patients with ACE-I-induced angioedema. ⋯ Icatibant was no more efficacious than placebo in at least moderately severe ACE-I-induced angioedema of the upper airway.