Annales pharmaceutiques françaises
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Since the 1970s, drugs unused by French households have been collected for humanitarian aid. In 1993, the Cyclamed system was created by pharmacists in order to manage and collect unused drugs. ⋯ In France this practice has been forbidden since the 1st of January 2009. Associations that still desire to send unused drugs to developing countries must develop other approaches, such as essential generic medicines or emergency health kits.
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Preparation in advance of intravenous solution could be efficient to improve quality assurance, security, time management and cost saving of drug delivery. The aim of this study was to investigate the stability of a mixture of diclofenac 75 mg/100 ml and sodium bicarbonate 42 mg/100 ml in 5% glucose polyolefin bags after freezing, long-term storage, and microwave thawing. ⋯ Within these limits, diclofenac in 5% glucose infusion may be prepared and frozen in advance by a centralized intravenous admixture service, then thawed before use in clinical units.
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Historical Article
[The story of Annales pharmaceutiques françaises. 1809-2009].
The Annales pharmaceutiques françaises is 200 years old. Initially, in 1809, the Bulletin de pharmacie was the organ of the Société de pharmacie de Paris. The journal was one of the dynamic events stimulated by the law of Germinal in year XI of the French revolution (1803). ⋯ It was in 1943 that the journal took on its current name of the Annales pharmaceutiques françaises. The journal is now the official organ of the French National Academy of Pharmacy. The six annual issues are supplemented by an internet diffusion allowing readers access in all French-speaking countries.
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The widely used term "overdose" denotes a toxic effect: opioid-induced intoxication and a mechanism: the poisoning results only from an overdose. Surprisingly, our understanding of the pathophysiology of this deadly complication is limited. In drug users, we attempted to: (1) improve knowledge of drug-induced respiratory effects; (2) clarify the mechanisms of drug interactions; (3) identify factors of variability and vulnerability. ⋯ The interaction results from a pharmacokinetic process. In contrast, methadone causes a dose-dependent decrease in PaO(2,) even significant before hypercapnia. We are assessing the relationships between on one hand alterations of ventilatory pattern and of arterial blood gas and on the other hand the different types of opiate receptors in the rats.
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Acute head injury is a common reason for seeking care in an emergency department and in France accounts for more than 500 consultations daily. In most cases, though the trauma is minor/moderate, a computed tomography scan is necessary to establish the diagnosis and avoid medical and/or social sequelae. This examination is however expensive and not always readily available in the emergency setting. ⋯ Due to specificity of its cellular expression, S100B protein is a useful biological marker of acute neurological disorders, such as ischemic or hemorrhagic stroke, and traumatic brain injury. This brief review exposes the contribution of S100B measurement in biological fluids to the diagnosis, the follow-up, and the prognosis of acute minor/moderate head injury. In addition, we describe the French STIC-S100 study, a cohort study designed to determine the negative prognostic value of early determination of plasma S100B levels for the diagnosis of minor/moderate head injury and its medical/social consequences.