Prescrire international
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Prescrire international · Dec 2014
ReviewAntibiotic therapy for acute uncomplicated pyelonephritis in women. Take resistance into account.
Acute uncomplicated pyelonephritis is a bacterial infection of the renal parenchyma, common in women. The bacterium responsible is usually Escherichia coli. Empirical antibiotic therapy should be initiated promptly to prevent serious complications. ⋯ Given the rapid development of bacterial resistance, broader-spectrum antibiotics should not be used as empirical therapy, to preserve their efficacy in serious infections. The empirical treatment should be adjusted as soon as the results of antimicrobial susceptibility testing are known. Whenever possible, it is preferable to avoid the use of fluoroquinolones and third-generation cephalosporins in non-serious infections such as cystitis.
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Prescrire international · Dec 2014
Randomized Controlled TrialGlycopyrronium + indacaterol. A fixed-dose combination with no advantages in COPD.
No more effective than tiotropium combined with formoterol.