Prescrire international
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(1) Fibromyalgia is characterised by a range of symptoms that include muscle pain, fatigue and sleep disorders. Anxiety and depression are often also present. The cause is unknown. ⋯ The best-assessed alternative therapies (acupuncture and physical exercise) only have a limited effect; (9) In practice, when a patient presents with symptoms compatible with fibromyalgia, the first step is to rule out a treatable condition. Quality of life may be improved by first acknowledging that the pain is real, and possibly by providing psychological, medical, social and occupational support. The limited efficacy of available drugs, and their potential adverse effects, should be discussed with the patient.
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Prescrire international · Aug 2009
Caspofungin: new indication. Same indications in children as in adults.
Caspofungin is no more effective than amphotericin B in children but its adverse effect profile is somewhat different. Caspofungin has not been compared with azole antifungals.