Yonsei medical journal
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Yonsei medical journal · May 2012
Hereditary thrombophilia in Korean patients with idiopathic pulmonary embolism.
Hereditary thrombophilia (HT) is a major risk factor for idiopathic pulmonary embolism (iPE) and shows different prevalence among ethnic groups. The prevalence and clinical characteristics of HT in Korean patients with iPE were investigated. ⋯ In this study of Korean patients, about half of the patients with iPE had HT. Patients with iPE and HT were mostly young males with deep venous thrombosis (DVT), previous venous thromboembolism (VTE), and frequent adverse clinical outcomes. Therefore, Korean patients with iPE should be tested for HT.
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Yonsei medical journal · May 2012
Myeloperoxidase expression in acute myeloid leukemia helps identifying patients to benefit from transplant.
Despite extensive study, the use of allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia (AML) vary considerably. The decision of which of these options to choose is complex and depends on both clinical and molecular variables as well as the availability and histocompatability of donor stem cells. So far there is no clear explanation on whether the expression of myeloperoxidase (MPO) relates to the prognosis of AML. ⋯ MPO expression at diagnosis helps to choose therapy for each AML patient and can differentiate AML patients who need transplantation.