Yonsei medical journal
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Yonsei medical journal · Sep 2013
Randomized Controlled TrialEfficacy of combination of meloxicam and pregabalin for pain in knee osteoarthritis.
Osteoarthritic pain is largely considered to be inflammatory pain. Sensory nerve fibers innervating the knee have been shown to be significantly damaged in rat models of knee osteoarthritis (OA) in which the subchondral bone junction is destroyed, and this induces neuropathic pain (NP). Pregabalin was developed as a pain killer for NP; however, there are no reports on pregabalin use in OA patients. The purpose of this study was to investigate the efficacy of pregabalin for pain in OA patients. ⋯ Meloxicam+pregabalin was effective for pain in OA patients. This finding suggests that OA pain is a combination of inflammatory and NP.
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Yonsei medical journal · Sep 2013
Comparative StudyKidney function in living donors undergoing nephrectomy by sevoflurane or desflurane anesthesia.
Although there is no clinical evidence of nephrotoxicity with the volatile anesthetics currently used in general anesthesia, a better agent should be needed in terms of preserving postoperative renal function in living kidney donors who have only single remaining kidney. The purpose of the current retrospective, single-center study was to evaluate and compare renal function of living kidney donors after nephrectomy under either sevoflurane or desflurane anesthesia. ⋯ Sevoflurane and desflurane can be used safely as volatile anesthetics in donors undergoing nephrectomy.