Yonsei medical journal
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Yonsei medical journal · Dec 2020
Review Biography Historical ArticleThe Work of Oliver R. Avison in Comparison to that of Albert Schweitzer from a Post-Colonial Perspective.
Compared to Nobel Prize Laureate Albert Schweitzer, Oliver R. Avison is not well known. Seeking to achieve more international recognition for Avison, this article elaborates on Avison's work with hospital and educational institutions from a post-colonial perspective. ⋯ The current circumstances of Severance Hospital and Yonsei University in Korea, compared to that of the Albert Schweitzer Hospital in Lambaréné, are clear evidence of this. Avison's extraordinary missionary work did not reflect the more negative side effects of colonial heritage intertwined with mission work in the 19th Century. Avison's case should be better known as a model of ecumenical mission towards sustainable development.
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Yonsei medical journal · Dec 2020
Screening of Methylation Gene Sites as Prognostic Signature in Lung Adenocarcinoma.
Most lung adenocarcinoma (LUAD) patients are diagnosed at the advanced stage and have poor prognosis. DNA methylation plays an important role in the prognosis prediction of cancers. The objective of this study was to identify new DNA methylation sites as biomarkers for LUAD prognosis. ⋯ We identified the prognostic signature for LUAD by combining six DNA methylation sites. This could service as potential robust and specificity signature in the prognosis prediction of LUAD.
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Yonsei medical journal · Dec 2020
Combination Therapy by Tissue-Specific Suicide Gene and Bevacizumab in Intramedullary Spinal Cord Tumor.
Malignant gliomas are aggressive spinal cord tumors. In this study, we hypothesized that combination therapy using an anti-angiogenic agent, bevacizumab, and hypoxia-inducible glioblastoma-specific suicide gene could reduce tumor growth. ⋯ This study suggests that combination therapy using bevacizumab with the pEpo-NI2-SV-TK therapeutic gene could be useful for increasing its therapeutic benefits for intramedullary spinal cord tumors.
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Yonsei medical journal · Dec 2020
Assisted Breathing with a Diaphragm Pacing System: A Systematic Review.
Patients with respiratory failure associated with neurological dysfunction often require mechanical ventilator support, which poses increased economic burden and ventilator-associated complications. A diaphragm pacing system (DPS) is an implanted device that provides respiratory support for such patients. In this systematic review, we reviewed the literature to assess the safety and efficacy of DPS for patients with respiratory failure resulting from amyotrophic lateral sclerosis (ALS) or cervical spinal cord injuries. ⋯ Based on safety and efficacy results, we do not support using DPS to manage respiratory failure in patients with ALS or cervical spine injury.
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Yonsei medical journal · Dec 2020
Characteristics and Treatment Outcomes of Isoniazid Mono-Resistant Tuberculosis: A Retrospective Study.
Isoniazid (INH) mono-resistant tuberculosis (Hr-TB) is a highly prevalent type of drug-resistant TB, possibly associated with unfavorable treatment outcomes. However, definitive guidelines on an optimal treatment regimen and duration for Hr-TB are currently under discussion. We evaluated the characteristics and treatment outcomes of Hr-TB patients. ⋯ A tailored strategy targeting high-risk patients is imperative for improved treatment outcomes. Further research on the rapid and accurate detection of resistance to INH and other companion drugs is warranted.