Yonsei medical journal
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Yonsei medical journal · Jun 2020
The Combined Impact of Chronic Kidney Disease and Diabetes on the Risk of Colorectal Cancer Depends on Sex: A Nationwide Population-Based Study.
Although both chronic kidney disease (CKD) and diabetes mellitus (DM) are considered factors increasing the risk of colorectal cancer (CRC), their impact on CRC is not fully understood. This study was aimed to investigate the impact of CKD, DM, or both diseases on the risk of CRC and to evaluate sex differences therein. ⋯ In female, having both CKD and DM significantly increases the risk of CRC, compared with having CKD or DM alone. This study suggests a significant difference in the effect of CKD or DM on the risk of CRC according to sex.
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Yonsei medical journal · Jun 2020
Erratum to "Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells" by Zhang X, et al. (Yonsei Med J 2018;59(5):633-642.).
This corrects the article on p. 633 in vol. 59, PMID: 29869461.
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Yonsei medical journal · Jun 2020
Case ReportsCerebral Venous Sinus Thrombosis Associated with Dutasteride Use.
Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults with known risk factors of prothrombotic conditions, pregnancy, infection, malignancy, and drugs. Dutasteride is a 5α-reductase inhibitor that is used for benign prostate hypertrophy and androgenetic alopecia. To date, CVT caused by dutasteride use has not been reported. ⋯ Headache and diplopia improved after discontinuing dutasteride and starting anticoagulation. The results from this case report indicated dutasteride as a potential cause of CVT. Presumably, the increased estrogen level due to dutasteride use caused the formation of a thrombus.
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Yonsei medical journal · May 2020
Survey of Risk-Based Quality Management Status and Establishment of Operational Model in Clinical Trials.
With the release of the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use E6 addendum, it is very important to establish risk-based quality management systems which meet good clinical practice. The aim of this research was to propose for risk-based quality management practices in the organizations that conduct clinical trials in South Korea. ⋯ In the future, organizations conducting clinical and subsequent pilot studies trials in South Korea should follow these quality management practice to share information with each other.
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Yonsei medical journal · May 2020
Erratum to "Distinct Neural Correlates of Executive Function by Amyloid Positivity and Associations with Clinical Progression in Mild Cognitive Impairment" by Yoon HJ, et al. (Yonsei Med J 2019;60(10):935-943.).
This corrects the article on p. 935 in vol. 60, PMID: 31538428.