Yonsei medical journal
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Yonsei medical journal · Sep 2014
Relationship of vitamin D binding protein polymorphisms and lung function in Korean chronic obstructive pulmonary disease.
Multiple genetic factors are associated with chronic obstructive pulmonary disease (COPD). The association of gene encoding vitamin D binding protein (VDBP, GC) with COPD has been controversial. We sought to investigate the types of GC variants in the Korean population and determine the association of GC variants with COPD and lung function in the Korean population. ⋯ This study suggested that GC polymorphism might be associated with lung function and risk of COPD in Korean population. GC1S variant and genotype 1S-1S were more frequently observed in control than in COPD. Moreover, GC1S variant was more common in non-decliners than in rapid decliners among COPD.
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Yonsei medical journal · Sep 2014
Surgical experience with infective endocarditis and aortic root abscess.
This study was conducted to evaluate the surgical outcomes of active infective endocarditis with aortic root abscess formation. ⋯ Surgical treatment for active endocarditis with aortic root abscess is still challenging, and was associated with high operative mortality. Nevertheless, long-term survival was excellent with good functional capacity after recovery from the early postoperative period.
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Yonsei medical journal · Sep 2014
Clinical outcomes of initial dexamethasone treatment combined with a single high dose of intravenous immunoglobulin for primary treatment of Kawasaki disease.
To investigate the clinical effects of a single high dose intravenous immunoglobulin (IVIG) combined with initial dexamethasone as a primary treatment on Kawasaki disease (KD). ⋯ Initial combined therapy with dexamethasone and a single high-dose of IVIG resulted in an improved clinical course, in particular a shorter febrile period, less IVIG retreatment, and shorter hospital stay without worse coronary outcomes.
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Yonsei medical journal · Sep 2014
Randomized Controlled Trial Multicenter StudySafety and efficacy of conversion from twice-daily tacrolimus to once-daily tacrolimus one month after transplantation: randomized controlled trial in adult renal transplantation.
The purpose of this study was to compare once-daily tacrolimus with twice-daily tacrolimus in terms of safety, efficacy, and patient satisfaction. ⋯ Conversion from twice-daily tacrolimus to once-daily tacrolimus one month after transplantation is safe and effective.