Surgery
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Tissue samples from patients with pathologic ((p)) stage III colorectal cancer were tested for sensitivity to 5-fluorouracil (5-FU). On the basis of the results, patients were divided into 5-FU-sensitive and 5-FU-resistant groups, and both groups were treated with fluoropyrimidine (UFT) as postoperative adjuvant chemotherapy. Recurrence, 5-year survival rates, and 5-year recurrence-free survival rates were compared. ⋯ Administration of UFT as postoperative adjuvant therapy to 5-FU-resistant patients had no significant effect on outcome.
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Major medical advances occur during wartime because of the presence of a high concentration of overwhelming casualties and the resulting requirement for innovative solutions. Examples of these advances include the propagation of hospitals with sanitary conditions, the use of blood transfusions, dialysis, air transportation of casualties, and advancements in vascular reconstruction. ⋯ The approach to the injured soldier has involved every aspect of patient care to include prevention using body armor, hypotensive resuscitation, tourniquets, intravenous and topical hemostatic agents, and a proactive approach of aggressive correction of coagulopathy using blood products. These advances currently are being translated to civilian practice altering the care of the urban patient.
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Anticoagulant therapy is challenging to modern surgical practice because it complicates risks of bleeding and the need for allogeneic blood transfusions. In an aging population, there is extensive use of antiplatelet agents, and patients present for operations receiving these agents. Hemostatic inhibitors are reviewed here, including anticoagulants, platelet inhibitors (clopidogrel), low-molecular-weight heparins, pentasaccharide (fondaparinux), and other factor Xa inhibitors. Agents used to manage bleeding, including aprotinin, lysine analogs, desmopressin, and recombinant factor VIIa, are discussed.
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Major bile duct injuries remain a potentially devastating complication after laparoscopic cholecystectomy. A retrospective review was conducted of patients who underwent a biliary-enteric reconstruction of a biliary injury to assess their long-term outcome. ⋯ Bile duct injuries that require a biliary-enteric repair are commonly associated with long-term complications. Level of injury and likely timing of repair predict risk of postoperative stricture.