Archives of general psychiatry
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Arch. Gen. Psychiatry · Nov 2010
Comparative StudyRelationship between amygdala responses to masked faces and mood state and treatment in major depressive disorder.
Major depressive disorder (MDD) is associated with behavioral and neurophysiological evidence of mood-congruent processing biases toward explicitly presented, emotionally valenced stimuli. However, few studies have investigated such biases toward implicitly presented stimuli. ⋯ Emotional-processing biases occur in amygdala responses to sad faces presented below the level of conscious awareness in dMDD or rMDD individuals and to happy faces in HCs. By influencing the salience of social stimuli, mood-congruent processing biases in the amygdala may contribute to dysfunction in conscious perceptions and social interactions in MDD. Our data suggest, however, that the negative bias resolves and a positive bias develops in patients with MDD during selective serotonin reuptake inhibitor treatment.
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Arch. Gen. Psychiatry · Oct 2010
Randomized Controlled TrialDeep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder.
Obsessive-compulsive disorder (OCD) is a chronic psychiatric disorder that affects 2% of the general population. Even when the best available treatments are applied, approximately 10% of patients remain severely afflicted and run a long-term deteriorating course of OCD. ⋯ isrctn.org Identifier: ISRCTN23255677.