Arkhiv patologii
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In addition to discrepancy of clinical and anatomopathological diagnosis the author proposes several other criteria for assessment of quality of clinical diagnosis: hypo- and hyperdiagnosis, diagnosis of lethal complications, late diagnosis of the basic disease and fatal complications, diagnosis of iatrogenic complications, accuracy of formulation of the fanal diagnosis, use of biopsies for specification of clinical diagnosis and control of the patients' treatment. Complete computerization of the pathologist's workplace makes all these criteria most effective.
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Historical Article
[The role of Pathology Department of the I.M. Sechenov Moscow Medical Academy in the development of forensic medicine].
The chair of pathology has greatly contributed to establishment and development of prosector's speciality: training of pathologists, initiation of first clinico-anatomical conferences and their upgrading, introduction of novel morphological techniques and other advanced methods, publication of books, guidelines, manuals. The chair, A. ⋯ V. Davydovsky especially, contributed much to transformation of the pathology service in Russia after 1917.
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Using mathematic modelling of the secretion function of type II alveolocytes of the right lung intercellular surfactant production in treated and not treated rabbits with multi cavernous tuberculosis of the lung was evaluated. Correlation between its disorders and frequency of development and dissemination of atelectatic changes in the organ was revealed. Surfactant-dependent character of alveoli atelectasis in animals receiving a combination of antituberculosis drugs (isoniazide plus rifampycin plus etambutol), a direct effect of these drugs on membranes of the granular endoplasmic reticulum, formation of secretion granules was demonstrated. Daily intravenous administration of amboxol (25 mg/kg) for 14 days had a protective effect on type II alveolocytes, activated surfactant production, prevented alveoli from atelectasis.
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The hemodynamic concept of TD pathogenesis and morphogenesis is based on the vascular response initiated by neuroendocrine mechanisms. Their effect in grave wounds is potentiated by blood loss, shock, endotoxicosis as well as inadequate therapy. ⋯ Periodization of TD is suggested that takes into account its cyclicity and specificity of time distribution of therapeutic and diagnostic actions. Cerebral, pulmonary, renal, cardiac, gastro-intestinal and mixed forms of TD are distinguished.