Oral surgery, oral medicine, and oral pathology
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Oral Surg. Oral Med. Oral Pathol. · Sep 1987
Case ReportsRecurrent aphthous stomatitis of the Behçet's type: successful treatment with thalidomide.
A 48-year-old man with a 27-year history of debilitating recurrent aphthous stomatitis major and pustular skin lesions was treated successfully with thalidomide. Side effects have not been encountered during a 6-month symptom-free period, while he has taken 25 mg per day. The drug is currently unavailable in this country except for the treatment of leprosy. It is hoped that publication of the dramatic response to thalidomide in this one instance will encourage greater interest in this potentially useful drug.
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Oral Surg. Oral Med. Oral Pathol. · Aug 1987
Case ReportsAcyclovir and the treatment of herpetic whitlow.
The herpes simplex virus can cause both oral and cutaneous lesions. Herpetic whitlow is a cutaneous manifestation of a herpetic infection. ⋯ Acyclovir, an antiviral agent used in the treatment of herpes simplex virus infections, was administered in the treatment of herpetic whitlow. Controlled studies of acyclovir therapy for herpetic whitlow have not been done; however, its use by health care providers to treat the symptoms of herpetic whitlow and a review of the disease are discussed in this case report.
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Oral Surg. Oral Med. Oral Pathol. · Jul 1987
Clinical Trial Controlled Clinical TrialLingual numbness and speech articulation deviation associated with temporomandibular joint disk displacement.
A prospective investigation of 208 patients with painful, arthrographically verified temporomandibular joint disk displacement revealed that seven patients (3%) demonstrated lingual numbness associated with speech articulation impairment. The speech disorder was characterized primarily by a distortion in the production of /s,r,d, and t/. The lingual numbness and the speech disorder had in all cases started in association with a painful onset of permanent displacement of the temporomandibular joint disk. ⋯ In order to test the hypothesis that the condition of lingual nerve entrapment in the lateral pterygoid muscle does exist, the course of the nerve was studied at dissection in 52 specimens from 26 cadaver heads. In 49 of the specimens, the lingual nerve descended deep to the lateral pterygoid muscle as has been traditionally defined. However, in three specimens, the nerve passed through the inferior belly of the muscle, revealing the condition of lingual nerve entrapment.
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Oral Surg. Oral Med. Oral Pathol. · Jun 1987
Case ReportsTherapeutic use of chlorhexidine in bone marrow transplant patients: case studies.
Patients undergoing cytotoxic chemotherapy and radiation therapy often experience severe oral complications during and after treatment despite supervised oral hygiene and conventional antimicrobial regimens. The antimicrobial compound chlorhexidine is an effective topical prophylactic agent against oral mucositis and candidiasis. ⋯ In each case, there was clinical resolution of mucositis and a concomitant decrease in the oral microbial burden 1 week after chlorhexidine use began. This strongly suggests that, in addition to its value in protecting these severely immunocompromised patients from oral infection, chlorhexidine also offers a therapeutic benefit in the resolution of existing oral infections and of mucositis.
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Oral Surg. Oral Med. Oral Pathol. · Feb 1987
Case ReportsLichen planus pemphigoides: report of a case with oral lesions.
Lichen planus pemphigoides is a rare condition characterized by the coexistence of lichen planus and bullous pemphigoid. Oral lesions have been reported but have not been studied immunopathologically. ⋯ Fine keratotic striae on the anterior buccal mucosa were clinically consistent with oral lichen planus. Perilesional tissue associated with ulceration of the posterior buccal mucosa showed histologic and immunopathologic changes consistent with bullous pemphigoid.