Archives of neurology
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Malignant gliomas are the most common and aggressive primary brain tumors in adults. Despite optimal treatment with surgery, radiotherapy, and temozolomide, tumor recurrences are frequent and patients with malignant gliomas continue to have poor prognoses. Malignant gliomas are often highly vascularized, and significant advances have been made in the last few decades in our understanding of the mechanisms of tumor angiogenesis. Recently, bevacizumab, an antibody against vascular endothelial growth factor, has demonstrated significant activity in recurrent glioblastomas, resulting in US Food and Drug Administration approval and raising the prospect for other antiangiogenic drugs now entering clinical trials.
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Archives of neurology · Mar 2010
Efficacy and safety of levetiracetam in patients with glioma: a clinical prospective study.
To evaluate the efficacy and safety of levetiracetam in the management of epilepsy in patients with glioma. ⋯ The results of this study provide good evidence that levetiracetam is efficacious and safe in patients with epilepsy due to glioma.
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Archives of neurology · Jan 2010
Comparative StudyHospital care for patients experiencing weekend vs weekday stroke: a comparison of quality and aggressiveness of care.
We examined the quality and aggressiveness of care for the treatment of acute ischemic stroke (AIS) on weekends vs weekdays. Acute ischemic stroke is a leading cause of death and disability in the United States, and aggressive treatment must be provided within 3 hours for optimal patient outcomes. Because of this short treatment window for the administration of tissue plasminogen activator, patients need around-the-clock access to high-quality and aggressive care. ⋯ Patients experiencing AIS are more likely to receive tissue plasminogen activator on weekends than on weekdays. Patients experiencing AIS who are admitted on weekends are no more likely to die than those who are admitted on weekdays. Further research is necessary to understand differences in weekend vs weekday care.
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Archives of neurology · Dec 2009
Comparative StudyFunctional and cognitive outcome in prolonged refractory status epilepticus.
To determine the functional and cognitive outcomes of patients with prolonged refractory status epilepticus (PRSE) lasting 7 or more days despite the use of anesthetic agents for seizure suppression. ⋯ Despite the high mortality rate, survival with meaningful functional and cognitive recovery is possible after PRSE. Prolonged duration of status epilepticus alone should not be considered a reason to discontinue treatment.