Archives of neurology
-
Archives of neurology · Nov 2009
Multicenter StudySurvival profiles of patients with frontotemporal dementia and motor neuron disease.
Frontotemporal dementia and amyotrophic lateral sclerosis are neurodegenerative diseases associated with TAR DNA-binding protein 43- and ubiquitin-immunoreactive pathologic lesions. ⋯ Distinct patterns of survival profiles exist in patients with frontotemporal dementia and motor neuron disease, and overall survival may depend on the relative timing of the emergence of secondary symptoms.
-
Archives of neurology · Sep 2009
Randomized Controlled Trial Multicenter StudyDeterminants of the timing of symptomatic treatment in early Parkinson disease: The National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) Experience.
To assess the predictive value of baseline measures of impairment, disability, and quality of life for the timing of initiation of symptomatic treatment in early Parkinson disease (PD). ⋯ In early PD, greater impairment and disability and higher level of education are independently associated with an earlier need for symptomatic treatment.
-
Archives of neurology · Sep 2009
Strokes after cardiac surgery and relationship to carotid stenosis.
To critically examine the role of significant carotid stenosis in the pathogenesis of postoperative stroke following cardiac operations. ⋯ There is no direct causal relationship between significant carotid stenosis and postoperative stroke in patients undergoing cardiac operations. Combining carotid and cardiac procedures is neither necessary nor effective in reducing postoperative stroke in patients with asymptomatic carotid stenosis.
-
Archives of neurology · Sep 2009
Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis.
Neuropsychological deficits in patients with multiple sclerosis (MS) have been shown to be associated with the major pathological substrates of the disease, ie, inflammatory demyelination and neurodegeneration. Double inversion recovery sequences allow cortical lesions (CLs) to be detected in the brain of patients with MS. Modern postprocessing techniques allow cortical atrophy to be assessed reliably. ⋯ The burden of CLs and tissue loss are among the major structural changes associated with cognitive impairment in relapsing-remitting MS.