Archives of neurology
The most recent articles from:
Arch. Neurol.
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Archives of neurology · Jun 2008
Randomized Controlled Trial Comparative StudySerum urate as a predictor of clinical and radiographic progression in Parkinson disease.
To determine whether concentration of serum urate, a purine metabolite and potent antioxidant that has been linked to a reduced risk of Parkinson disease (PD), predicts prognosis in PD. ⋯ These findings identify serum urate as the first molecular factor directly linked to the progression of typical PD and suggest that targeting urate or its determinants could be an effective disease-modifying therapy in PD. Trial Registration clinicaltrials.gov Identifier: NCT00040404.