JACC. Heart failure
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JACC. Heart failure · May 2015
Multicenter StudyAssessing the use of international classification of diseases-10th revision codes from the emergency department for the identification of acute heart failure.
The objective of this study was to compare administrative codes with chart review for patients with acute heart failure (AHF). ⋯ An ICD-10 I50.x diagnosis in the ED is highly predictive of AHF compared with chart-level adjudication using a validated score. Thus, the use of these codes in ED administrative databases could identify AHF for clinical and epidemiological studies.
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JACC. Heart failure · Feb 2015
Multicenter StudyAdvance directives among hospitalized patients with heart failure.
The purpose of this study was to assess the frequency and correlates of documented advance directives (ADs) among patients hospitalized for heart failure (HF). ⋯ In a diverse population of hospitalized patients with HF, most did not have a documented AD in the medical records. Although several factors were associated with a higher probability, major opportunities exist for all subgroups of patients with HF to improve documentation of ADs.
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JACC. Heart failure · Feb 2015
Comparative StudyClinical outcomes with use of erythropoiesis stimulating agents in patients with the HeartMate II left ventricular assist device.
This study evaluated clinical outcomes associated with erythropoiesis stimulating agent (ESA) use in left ventricular assist devices (LVAD)-supported patients. ⋯ ESA use in LVAD patients is associated with higher rates of suspected PT.
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JACC. Heart failure · Feb 2015
Decongestion strategies and renin-angiotensin-aldosterone system activation in acute heart failure.
The purpose of this study was to assess the relationship between biomarkers of renin-angiotensin-aldosterone system (RAAS) activation and decongestion strategies, worsening renal function, and clinical outcomes. ⋯ High-dose loop diuretic therapy did not result in RAAS activation greater than that with low-dose diuretic therapy. UF resulted in greater PRA increase than stepped pharmacologic care. Neither PRA nor aldosterone was significantly associated with short-term outcomes in this cohort. (Determining Optimal Dose and Duration of Diuretic Treatment in People With Acute Heart Failure [DOSE-AHF]; NCT00577135; Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome [CARRESS]; NCT00608491).
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JACC. Heart failure · Jan 2015
Randomized Controlled Trial Multicenter StudyComparative assessment of short-term adverse events in acute heart failure with cystatin C and other estimates of renal function: results from the ASCEND-HF trial.
The purpose of this study was to investigate the predictive values of baseline and changes in cystatin C (CysC) and its derived equations for short-term adverse outcomes and the effect of nesiritide therapy on CysC in acute decompensated heart failure (ADHF). ⋯ Our findings confirmed the prognostic value of baseline CysC levels in the setting of ADHF. However, worsening renal function based on CysC rise was not predictive of adverse events. Nesiritide did not worsen renal function compared with placebo.