JACC. Heart failure
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JACC Heart Fail
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JACC. Heart failure · Feb 2013
Aldosterone antagonists and outcomes in real-world older patients with heart failure and preserved ejection fraction.
The purpose of this study was to examine the clinical effectiveness of aldosterone antagonists in older patients with heart failure and preserved ejection fraction (HF-PEF). ⋯ In older HF-PEF patients, aldosterone antagonists had no association with clinical outcomes. Findings from the ongoing randomized controlled TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) trial will provide further insights into their effect in HF-PEF.