Nihon yakurigaku zasshi. Folia pharmacologica Japonica
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Nippon Yakurigaku Zasshi · Aug 1982
[Anti-inflammatory, analgesic and anti-pyretic activities of a non-steroidal anti-inflammatory drug, etofenamate, in experimental animals].
Anti-inflammatory, analgesic, and anti-pyretic activities of orally administered etofenamate, the diethylene glycol ester of flufenamic acid, were investigated in experimental animals. Against acetic acid-induced vascular permeability in mice and ultra-violet light-induced erythema in guinea pigs, etofenamate produced a dose related inhibition at doses of 40--320 mg/kg and 5--20 mg/kg, respectively. In rats, felt-pellet-induced granuloma formation and adjuvant-induced arthritis were significantly inhibited by repeated administration of etofenamate at doses of 20 mg/kg/day for 5 days and 40 mg/kg/day for 21 days, respectively. ⋯ These potencies of etofenamate were 0.5 to 1.6 times those of flufenamic acid. In particular, the anti-erythema, anti-arthritis, and anti-pyretic activities of etofenamate were approximately equivalent to or superior to those of flufenamic acid. From these results, it was suggested that etofenamate given orally, like other non-steroidal anti-inflammatory drugs, showed anti-inflammatory, analgesic, and anti-pyretic activities in experimental animals.
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Nippon Yakurigaku Zasshi · Mar 1980
Comparative Study[Comparative studies on the hemodynamic effects of dobutamine, dopamine, and isoproterenol in dogs in experimental shock (author's transl)].
Cardiovascular effects of dobutamine (DOB), isoproterenol (Iso), and dopamine (DA) were compared in Beagle dogs weighing 6.8 to 11.6 kg under experimental shock produced by ligation of the left coronary arteries and intravenous administration of hexamethonium-Br (10 mg/kg). Intravenous infusion of DOB (1 approximately 20 microgram/kg/min) dose-dependently improved the hemodynamic state of shock by increasing left ventricular dp/dt (LV dp/dt), cardiac output (CO), and blood pressure. These improvements were also observed with the infusion of DA (20 approximately 40 microgram/kg/min). ⋯ Iso increased significantly only the venous return. Although increases of coronary flow with DOB and DA are probably mainly due to an increase of myocardial oxygen consumption, the increase of coronary perfusion pressure also may contribute to the increase of coronary flow. As a result, myocardial oxygen balance was improved with DOB or DA. alpha stimulation in the venous system as well as beta 1 stimulation apparently contributes to improvement of the deteriorated hemodynamic state, in experimental shock, as induced in dogs.