The American journal of gastroenterology
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Am. J. Gastroenterol. · Jul 2009
Comparative StudyEpistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease.
Recent data suggest functional interactions between NOD2 and other receptors of the innate immune system modulating inflammatory responses. Here we analyzed the role of Toll-like receptor 9 (TLR-9) gene variants with respect to susceptibility to inflammatory bowel disease (IBD) and tested for genetic interactions with NOD2 and other susceptibility genes for Crohn's disease (CD). ⋯ Our results provide evidence for genetic interactions between polymorphisms in TLR9 and CD-associated variants in NOD2, IL23R, and DLG5, differentially modulating CD susceptibility.
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Non-anesthesiologist-administered propfol (NAAP) sedation for endoscopic procedures remains controversial despite the overwhelming evidence that with proper training and patient selection, NAAP is safe and results in improved time to sedation and recovery when compared with standard sedation with a combination of an opioid and benzodiazepine. Emerging data suggest that NAAP also results in an improved psychomotor recovery. Can our patients return to meaningful tasks such as driving with NAAP after recovery in the endoscopy suite?