The American journal of gastroenterology
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Am. J. Gastroenterol. · May 2008
A significant decline in the American domination of research in gastroenterology with increasing globalization from 1980 to 2005: an analysis of American authorship among 8,251 articles.
To determine whether the relative American contribution to gastroenterology research, as determined by authorship in journals, decreased from 1980 to 2005. ⋯ From 1980 to 2005, American representation in American gastroenterologic journals significantly declined, whereas American representation in European gastroenterologic journals moderately increased. The latter finding, together with increased transnational collaboration and increased international representation in editorial boards, suggests that increasing globalization of information, partly due to computers and the Internet, may be an important etiologic factor. This may result in an improving quality of research performed outside America. Other potential etiologic factors include improving standard of living outside America and increasing clinical volume of academic gastroenterologists in America.
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Am. J. Gastroenterol. · Apr 2008
Hospitalizations for upper and lower GI events associated with traditional NSAIDs and acetaminophen among the elderly in Quebec, Canada.
The risk of upper/lower gastrointestinal (GI) adverse events associated with the concomitant use of traditional nonsteroidal anti-inflammatory drugs (tNSAIDs) with acetaminophen has not been assessed. Among users of these drugs, the concomitant use of proton pump inhibitors (PPIs) with tNSAIDs may reduce the risk of upper GI adverse events, but its effect on lower GI events is not clear. ⋯ Among elderly patients requiring analgesic/anti-inflammatory treatment, use of the combination of a tNSAID and acetaminophen may increase the risk of GI bleeding compared with either agent alone.
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Am. J. Gastroenterol. · Mar 2008
Randomized Controlled Trial Comparative StudyWarm water or oil-assisted colonoscopy: toward simpler examinations?
Completion rates, pain, and difficulties during the exam are still problems in colonoscopy. New methods of lubrication, rarely considered a matter of study, may help in this respect. Our aim was to compare an oil-assisted technique with a modified warm water method applied during colonoscopy. ⋯ Warm water and oil-assisted colonoscopy could be simple, safe, and inexpensive methods for easier and less painful examinations.
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Am. J. Gastroenterol. · Mar 2008
ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands.
Inflammatory bowel disease (IBD)--Crohn's disease (CD) and ulcerative colitis (UC)--and celiac disease are intestinal inflammatory disorders with a complex genetic background. Recently, two novel genes were found to be associated with IBD susceptibility. One, an uncommon coding variant (rs11209026) in the gene encoding for the interleukin-23 receptor (IL23R), conferred strong protection against CD. The other, rs2241880 in the autophagy-related 16-like 1 gene (ATG16L1), was associated with CD. We performed a case-control study for the association of IBD with IL23R and ATG16L1 in a Dutch cohort. We also looked at the association of IL23R and ATG16L1 with celiac disease. ⋯ We confirmed the association of IL23R and ATG16L1 with CD susceptibility and also the association of IL23R with UC. We found IL23R and ATG16L1 were not associated with celiac disease susceptibility.
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Am. J. Gastroenterol. · Jan 2008
Randomized Controlled Trial Comparative StudyPreoperative versus postoperative Helicobacter pylori eradication therapy in gastric cancer patients: a randomized trial.
Helicobacter pylori (H. pylori) eradication is strongly recommended for gastric cancer patients who undergo subtotal gastrectomy. The efficacy of proton pump inhibitor-based triple therapy for H. pylori eradication has not been adequately assessed in the gastric remnant. The aim of this study was to compare the efficacy of postoperative versus preoperative H. pylori eradication therapy. ⋯ In distal gastric cancer patients, the effect of proton pump inhibitor-based triple therapy for H. pylori eradication was not different whether given postoperatively or preoperatively.