European heart journal. Acute cardiovascular care
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Eur Heart J Acute Cardiovasc Care · Sep 2013
Observational StudyFGF-23 is associated with increased disease severity and early mortality in cardiogenic shock.
Despite the increased use of percutaneous interventions, infarction-related cardiogenic shock (CS) is still associated with high mortality. Biomarkers might be helpful to identify patients at risk, and point towards novel therapeutic strategies in CS. The phosphaturic hormone fibroblast growth factor 23 (FGF-23) has recently been introduced as a predictor for mortality in patients with chronic systolic heart failure. However, its predictive role in CS has not been investigated so far. ⋯ In CS, a tremendous increase in FGF-23 occurs, and high levels of FGF-23 are associated with poor outcome.